Simple and Sensitive Spectrophotometric Method for the Determination of Bicalutamide in Bulk and Formulations

A.Anton Smith*, R. Manavalan and K.Kannan Department of Pharmacy, Annamalai University, Annamalainagar608 002. Tamilnadu, India ∗ E-mail: [email protected] ______________________________________________________________________________ ABSTRACT A sensitive, extraction, derivatizatation, evaporation and complexation free, direct spectrophphotometric method is developed for the determination of Bicalutamide (BCA) in bulk drugs and pharmaceutical preparation. The optimum conditions for the analysis of the drug are established. The method permits the determination of BCA over a concentration range of 2.5 μg/ml 12.5 μg/ml. Detection and quantification limits are calculated. The obtained results showed good recoveries of 98.279 with relative standard deviation of 0.35. The repeatability and reproducibility of BCA in methanol is determined. Precision and accuracy of the developed method is used for recovery study. The proposed method is applicable for the assay of BCA investigation in dosage forms and the results are in good agreement.